Participation of dopaminergic system in the dynamics of behavioral reactions of aging rats of both sexes under daily testing in the open field

Under daily testing of aging rats both sexes in the open field a slow lowering motion activity is observed: by 6th day experiment passed distance male reduces 41% (р≤0.01), and female – 46% (р≤0.05) comparison to background values. The blockade monoamine oxidase-B (МАО-В) selegiline (intraperitoneal Introduction 5 mg/kg one hour before testing) does not significantly change orientation intensity this process, but probably contribute formation more comfortable psycho-emotional state animals. Consequently, central dopamine cannot prevent from process under testing, at least, frames method used research. We obtained evidence favor fact that suppression rather connected with animals’ loss motivation for research than growing anxiety.